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Heart Disease

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IV Sildenafil Safe and Effective for Pulmonary Hypertension in Neonates

IV Sildenafil Safe and Effective for Pulmonary Hypertension in Neonates

Intravenous sildenafil safely improves oxygenation in critically ill neonates with persistent pulmonary hypertension of the newborn. These findings, the results of an open-label, dose-escalation trial, are reported in the December issue of the Journal of Pediatrics. Despite a recent report that enteral... (Continue reading)

Can Statins Prevent and Treat Infection?

Can Statins Prevent and Treat Infection?

Results from a new meta-analysis suggest that the pleiotropic effects of statins are useful in the treatment and prevention of different infections, including bacteremia, pneumonia, and sepsis Our pooled adjusted estimate from observational studies suggests that patients who have infections Dr... (Continue reading)

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Warfarin Use Common and Increasing Among Injured Adults

Many adult trauma patients are using warfarin at the time of their injury, and in the last few years there has been a marked increase in use in this patient population Moreover, as might be expected, patients with warfarin on board... (Continue reading)

Manage Drug Interactions Between Clopidogrel and Proton-Pump Inhibitors?

Manage Drug Interactions Between Clopidogrel and Proton-Pump Inhibitors?

clopidogrel is the sixth most commonly dispensed medication in the United States.Indicated to reduce the rates of antithrombotic events in patients with a recent cardiovascular event, clopidogrel plays an integral role in the care of patients after myocardial infarction, stroke, or... (Continue reading)

Atrial Fibrillation Can Be Prevented By Corticosteroids

Atrial Fibrillation Can Be Prevented By Corticosteroids

corticosteroids can reduce and prevent Atrial Fibrillation after cardiac surgery in 50% of patient. This therapy has a very favorable risk/benefit ratio and should be considered in all patients undoing cardiopulmonary bypass,” co-author Dr. Paul E. Marik noted in an email... (Continue reading)

ECG Screening of Athletes Catches Potentially Lethal Heart Abnormalities

ECG Screening of Athletes Catches Potentially Lethal Heart Abnormalities

Implementing the “Lausanne recommendations” for pre-participation cardiovascular screening identifies athletes with occult heart conditions that could place them at risk for sudden cardiac arrest during vigorous physical activity, investigators report. The Lausanne recommendations call for a personal and family history, physical... (Continue reading)

FDA Approves Aliskiren/Valsartan Combo for Hypertension

The US Food and Drug Administration (FDA) has approved a single-pill combination of the direct renin inhibitor aliskiren and the angiotensin receptor blocker valsartan (Valturna, Novartis Pharmaceuticals Corp) for the treatment of hypertension in patients not adequately controlled on either... (Continue reading)

Possible interaction between clopidogrel and (PPIs)

Possible interaction between clopidogrel and (PPIs)

EMEA(European Medicines Agency) issued statement on a possible interaction between clopidogrel (Plavix) and proton-pump inhibitors (PPIs) and has recommended that the product information for all clopidogrel-containing medicines be amended to discourage concomitant use of PPIs unless absolutely necessary The UK... (Continue reading)

Simvastatin Lowers Portal Pressure

Simvastatin Lowers Portal Pressure

Simvastatin is effective in lowering portal pressure and improving liver perfusion in patients with cirrhosis, according to findings published in the May issue of Gastroenterology “Simvastatin improves liver generation of nitric oxide and hepatic endothelial dysfunction in patients with cirrhosis, so... (Continue reading)

Statin Improve Mortality

Statin Improve Mortality

Statin therapy after a first stroke reduces the 10-year risk of recurrent stroke, a new study has shown Statin use also reduced the risk of mortality, even after adjustment for potential confounders, such as blood-pressure control, report investigators. Given the global... (Continue reading)

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