Asmall study show that Chewable Aspirin Is Better Absorbed Than Regular Aspirin,

In the  study, the volunteers (13 male; average age 31 years) were given supratherapeutic doses of aspirin, 1950 mg, as either a solid tablet swallowed, a solid tablet chewed then swallowed, or chewable tablets. They were given the aspirin with water after fasting for six hours, with a washout period of seven days between crossovers.

Chewable Aspirin

The mean peak concentrations of aspirin were seen at three hours in all groups and were 10.4, 11.3 and 12.2 mg/dL in the solid-swallowed, solid-chewed, and chewable groups, respectively; this was statistically significant in each group (p<0.05), except in comparing solid-swallowed with solid-chewed groups. All subjects in the chewable-aspirin group had measurable salicylate levels at 45 minutes after ingestion, compared with no measurable salicylate levels in six of 14 in the solid-swallowed group and one of 14 in the solid-chewed group at 60 minutes,

“Our data demonstrate that the formulation of aspirin as well as chewing the tablet increases the rate and completeness of absorption. These data suggest that in the treatment of ACS, a chewable formulation may be preferable to solid tablets chewed or swallowed,” Nordt and colleagues state.

“However, large prospective studies in patients being treated with ACS are needed to see if this is clinically significant,” they conclude.